Detailed map of a cis-regulatory input function
نویسندگان
چکیده
منابع مشابه
Detailed map of a cis-regulatory input function.
Most genes are regulated by multiple transcription factors that bind specific sites in DNA regulatory regions. These cis-regulatory regions perform a computation: the rate of transcription is a function of the active concentrations of each of the input transcription factors. Here, we used accurate gene expression measurements from living cell cultures, bearing GFP reporters, to map in detail th...
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The transcription rate of a gene is often controlled by several regulators that bind specific sites in the gene's cis-regulatory region. The combined effect of these regulators is described by a cis-regulatory input function. What determines the form of an input function, and how variable is it with respect to mutations? To address this, we employ the well-characterized lac operon of Escherichi...
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Stochastic effects of regulatory molecules in low copy numbers per cell in transcriptionregulation process have now been recognized as a major physiologically and evolutionarily important factor in the development and function of many living organisms. The transcription rate of a gene is often controlled by several regulators that bind specific sites in the gene’s cis-regulatory region. The com...
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Precise gene expression is a fundamental aspect of organismal function and depends on the combinatorial interplay of transcription factors (TFs) with cis-regulatory DNA elements. While much is known about TF function in general, our understanding of their cell type-specific activities is still poor. To address how widely expressed transcriptional regulators modulate downstream gene activity wit...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2003
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1230759100